A study examined how social determinants of health (SDoH) affect health outcomes for people of Black ethnicities living with HIV in England. Researchers conducted questionnaires, focus groups, and interviews with 340 participants, finding three main SDoH patterns: livelihood, shelter/displacement, and social exclusion. The study found that higher SDoH scores were linked to increased odds of multimorbidity, with specific adjusted odds ratios indicating significant associations. Higher scores in livelihood and social exclusion were correlated with all domains of quality of life, while shelter/displacement was particularly associated with issues in usual activities and pain/discomfort. Qualitative data supported these results, illustrating how SDoH interconnect and impact health. The findings stress the importance of addressing these determinants through comprehensive interventions to reduce health inequities for this population.