A recent study examined the relationship between circadian syndrome (CirS), instrumental activities of daily living (IADL) disability, and cardiometabolic multimorbidity (CMM) in middle-aged and older adults in China. The study involved 8,085 participants in cross-sectional analysis and 5,887 in longitudinal analysis. Researchers used logistic regression models to explore associations between CirS and CMM, and Cox proportional hazard regression models to evaluate the impact of CirS on the onset of CMM.

Results showed that CirS was significantly linked to CMM, particularly when six or more components of CMM were present. During a seven-year follow-up, 452 new CMM cases were observed, with hazard ratios indicating a strong connection between CirS and CMM. The combination of CirS and IADL disability also exhibited a notable relationship with new-onset CMM. Furthermore, IADL disability was found to mediate 8.37% of the effect of CirS on the progression to CMM. These findings suggest that addressing CirS and IADL disability could be vital in preventing CMM among older adults.