A study evaluated the EXOTIC upper limb exoskeleton, aimed at helping individuals with severe disabilities perform daily activities. The system uses a tongue-based control interface and intelligent computer vision assistance. Six participants with tetraplegia tested the device and took about one minute to drink from a bottle or toggle a light switch. They averaged 1.5 minutes to eat a strawberry or scratch their heads. Results indicate the potential for the EXOTIC system to enhance independence for those with complete functional tetraplegia. The study also highlighted important design considerations, such as the need for adaptability to various lean angles in wheelchairs and the increased stiffness of the device’s fingers. Additionally, the research introduced a hybrid deep learning model for automated wrist fracture detection, which may improve diagnostic accuracy, efficiency, and timeliness for clinicians.