A study published in BMC Cancer examines the impact of cognitively challenging physical activity (PA) on children and adolescents undergoing cancer treatment. Young cancer patients often face physical and cognitive challenges, particularly affecting executive functions (EFs). The research aims to determine whether engaging in cognitively stimulating PA can enhance cognitive and physical performance and improve mental health during acute cancer care.

Conducted across four pediatric oncology centers in Switzerland, the prospective study divides participants into two groups: one receiving cognitively challenging PA and the other receiving standard care plus PA recommendations. The intervention involves three weekly 45-minute sessions over twelve weeks, focusing on integrating cognitive elements into PA. Assessments will measure EFs, motor skills, cardiovascular health, quality of life, and psychosocial functioning at various intervals.

This study is the first of its kind to implement such tailored PA for pediatric cancer patients, with the goal of activating brain networks that support higher-order cognitive processes. The findings could lead to improved care standards and enhance the quality of life for childhood cancer survivors. The study is registered with ClinicalTrials.gov and the German Clinical Trial Register.