Pediatric palliative care aims to enhance the quality of life for children with cancer and other life-limiting conditions. As the population of eligible children grows, there is a greater need for multidisciplinary care approaches and personalized strategies. A systematic review analyzed interventions effective in pediatric palliative care, focusing on children aged 0 to 2 years. The review identified ten key studies highlighting the significance of a multimodal approach. Effective interventions include the use of sedative medications for symptom management, electronic symptom monitoring to boost family engagement, pain therapy, and home care, which is favored by many families. The findings emphasize the necessity of a care model that combines various strategies and involves a multidisciplinary team to ensure the best outcomes for critically ill children. However, the review noted a lack of specific studies addressing the 0-2 age group and the absence of standardized protocols, which pose challenges to clinical practice.