A study published in Front Public Health highlights the significant prevalence of depression among female sex workers (FSW) in low- and middle-income countries, specifically focusing on mothers in Kenya, Nigeria, and the Democratic Republic of the Congo. Utilizing the Edinburgh Postnatal Depression Scale (EPDS), researchers surveyed 831 mothers who are FSW, revealing a staggering 96.5% prevalence of probable depression, with a mean EPDS score of 22.3. The highest scores were recorded in the DRC (24.6) and among younger participants aged 18-24 (23.3). Participants reported feelings of desperation, financial insecurity, and trauma, all correlating with suicidal thoughts. The study emphasizes the utility of the EPDS as a low-cost screening tool for identifying depression and facilitating referrals for treatment. It underscores the urgent need for targeted mental health interventions, social programs, and legal protections to improve the well-being of this vulnerable population.