Most people with mental health conditions worldwide do not receive specialized care. To address this issue, training non-specialists to provide brief, structured psychological interventions has shown promise. However, choosing the right intervention for various populations and contexts in low-resource settings can be difficult. This article provides an overview of ten effective psychological interventions that can be delivered by non-specialists, based on randomized controlled trials. These interventions include Cognitive Processing Therapy, Common Elements Treatment Approach, Counseling for Alcohol Problems, Friendship Bench, Group Interpersonal Therapy, Healthy Activity Program, Problem Management Plus, Self-Help Plus, Step-by-Step, and the Thinking Healthy Programme. Each intervention has proven effective for different conditions, such as depression and posttraumatic stress disorder, in various environments. The article also discusses important factors in selecting interventions, including treatment duration, which ranges from 4 to 16 sessions, and the training time required for non-specialists, which spans from 5 to 12 days. This guide aims to assist in choosing suitable psychological interventions tailored to the needs of specific populations and available resources.