A study examining individuals experiencing homelessness in Madrid reveals significant levels of discrimination affecting their mental health. Researchers conducted structured interviews with 355 participants, finding that over half reported experiences of theft, property damage, and unfair treatment by law enforcement, along with threats and assaults. Nearly one-third experienced unfair loss of close relationships and discrimination in the labor and housing markets, as well as in public transportation and businesses. The group facing the highest discrimination was generally younger, included more women, and had a higher proportion of Spanish-born individuals. Their homelessness histories were more complex, often involving youth-onset homelessness and unsheltered living, along with greater involvement in prostitution and survival sex. Those who reported more discrimination experiences showed higher rates of disabilities, mental health issues, substance abuse, and symptoms of anxiety, depression, and complex posttraumatic stress disorder. The findings emphasize the need for targeted interventions and tailored services to address the intersectional vulnerabilities and psychosocial factors impacting mental health among this population.