A systematic review evaluated the effectiveness of chlorhexidine (CHX)-containing products in improving gingival health for patients with intellectual disabilities. Researchers conducted an electronic search across three databases from 1945 to December 2024. Twelve randomized controlled trials, involving individuals with special health care needs, were analyzed. The study found that CHX use significantly reduced plaque accumulation and gingival inflammation, particularly with 0.2% CHX formulations. The greatest reductions in plaque were noted with spray and gel delivery methods. The review highlighted that short-term use of CHX (4-6 weeks) was beneficial and well-tolerated, despite common mild side effects like tooth staining and taste alterations. These results support the inclusion of CHX as an adjunct to mechanical oral hygiene practices for individuals with special health care needs, emphasizing the need for tailored use and close monitoring by dental providers to minimize complications.